ABCG2 modulates chlorothiazide permeability in vitro – characterization of the interaction

We are showing that chlorothiazide, a diuretic, is an ABCG2 substrate. It is a Biopharmaceutics Classification System/Biopharmaceutics Drug Distribution and Classification System (BCS/BDDCS) Class IV drug with low bioavailability. Therefore, we tested if chlorothiazide interacts with major apic...

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Bibliographic Details
Main Authors:	Beéry Erzsébet Narozsnikné Rajnai Zsuzsanna Abonyi Tibor Makai Ildikó Bánsághi Száva Erdő Franciska Sziráki István Herédi-Szabó Krisztina Kis Emese Jani Márton Márki-Zay János Tóth Gábor Krajcsi Péter
Format:	Article
Published:	2012
Series:	DRUG METABOLISM AND PHARMACOKINETICS 27 No. 3
Subjects:	Farmakológia és gyógyszerészet
doi:	10.2133/dmpk.DMPK-11-NT-068
mtmt:	1765884
Online Access:	https://publikacio.ppke.hu/2382

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