ABCG2 modulates chlorothiazide permeability in vitro – characterization of the interaction

We are showing that chlorothiazide, a diuretic, is an ABCG2 substrate. It is a Biopharmaceutics Classification System/Biopharmaceutics Drug Distribution and Classification System (BCS/BDDCS) Class IV drug with low bioavailability. Therefore, we tested if chlorothiazide interacts with major apic...

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Bibliographic Details
Main Authors: Beéry Erzsébet
Narozsnikné Rajnai Zsuzsanna
Abonyi Tibor
Makai Ildikó
Bánsághi Száva
Erdő Franciska
Sziráki István
Herédi-Szabó Krisztina
Kis Emese
Jani Márton
Márki-Zay János
Tóth Gábor
Krajcsi Péter
Format: Article
Published: 2012
Series:DRUG METABOLISM AND PHARMACOKINETICS 27 No. 3
Subjects:
Farmakológia és gyógyszerészet
doi:10.2133/dmpk.DMPK-11-NT-068

mtmt:1765884
Online Access:https://publikacio.ppke.hu/2382

Internet

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