Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC3.4.14.5) produces naloxone-reversible analgesia in rats

The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces st full, dose-dependent, short-lasting and naloxone- reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longit...

Full description

Bibliographic Details
Main Authors: Rónai András
Timár Júlia
Mako E
Erdő Franciska
Gyarmati Zsuzsanna
Tóth Géza
Orosz György
Fürst Zsuzsanna
Székely József Iván
Format: Article
Published: 1998
Series:LIFE SCIENCES 64 No. 2
Subjects:
Farmakológia és gyógyszerészet
doi:10.1016/S0024-3205(98)00544-X

mtmt:117447
Online Access:https://publikacio.ppke.hu/2338

Internet

Dokumentum-elérés

Similar Items