Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC3.4.14.5) produces naloxone-reversible analgesia in rats
The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces st full, dose-dependent, short-lasting and naloxone- reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longit...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1998
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| Sorozat: | LIFE SCIENCES
64 No. 2 |
| Tárgyszavak: | |
| doi: | 10.1016/S0024-3205(98)00544-X |
| mtmt: | 117447 |
| Online Access: | https://publikacio.ppke.hu/2338 |