Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC3.4.14.5) produces naloxone-reversible analgesia in rats

The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces st full, dose-dependent, short-lasting and naloxone- reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longit...

Full description

Bibliographic Details
Main Authors: Rónai András
Timár Júlia
Mako E
Erdő Franciska
Gyarmati Zsuzsanna
Tóth Géza
Orosz György
Fürst Zsuzsanna
Székely József Iván
Format: Article
Published: 1998
Series:LIFE SCIENCES 64 No. 2
Subjects:
Farmakológia és gyógyszerészet
doi:10.1016/S0024-3205(98)00544-X

mtmt:117447
Online Access:https://publikacio.ppke.hu/2338

MARC

LEADER 00000nab a2200000 i 4500
001 publ2338
005 20250307110911.0
008 250307s1998 hu o 0|| Angol d
022 |a 0024-3205 
024 7 |a 10.1016/S0024-3205(98)00544-X  |2 doi 
024 7 |a 117447  |2 mtmt 
040 |a PPKE Publikáció Repozitórium  |b hun 
041 |a Angol 
100 1 |a Rónai András 
245 1 0 |a Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC3.4.14.5) produces naloxone-reversible analgesia in rats  |h [elektronikus dokumentum] /  |c  Rónai András 
260 |c 1998 
300 |a 145-152 
490 0 |a LIFE SCIENCES  |v 64 No. 2 
520 3 |a The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces st full, dose-dependent, short-lasting and naloxone- reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longitudinal muscle strip of guinea-pig ileum bioassay. Two of the potential DP IV substrates, morphiceptin and endomorphin 1, identified recently in bovine brain were also analgesic given by similar route. The action of endomorphin 1 was more potent (ED50 = 7.9 nmol/rat) and slightly but significantly more sustained than that of Diprotin A. Diprotin A neither potentiated nor prolonged the effect of a marginally analgesic dose of endomorphin 1. The distinct time course and the lack of potentiation indicate that in the analgesic effect of Diprotin A. in rats the protection of a brain Tyr-Pro-peptide other than endomorphin 1 is involved. 
650 4 |a Farmakológia és gyógyszerészet 
700 0 1 |a Timár Júlia  |e aut 
700 0 1 |a Mako E  |e aut 
700 0 1 |a Erdő Franciska  |e aut 
700 0 1 |a Gyarmati Zsuzsanna  |e aut 
700 0 1 |a Tóth Géza  |e aut 
700 0 1 |a Orosz György  |e aut 
700 0 1 |a Fürst Zsuzsanna  |e aut 
700 0 1 |a Székely József Iván  |e aut 
856 4 0 |u https://publikacio.ppke.hu/id/eprint/2338/1/lifescience1999.pdf  |z Dokumentum-elérés  

Similar Items