Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats.

TAK-285, an investigational, orally active HER2/EGRF inhibitor is in clinical development for potential use in HER2 over-expressing metastatic breast cancer. The objective of the present work was to verify the presence of unbound TAK-285 in the rat brain after oral administration by a microdialysis...

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Bibliographic Details
Main Authors:	Erdő Franciska Gordon J Wu JT Sziraki I
Format:	Article
Published:	2012
Series:	BRAIN RESEARCH BULLETIN 87 No. 4-5
Subjects:	Idegtudományok (benne pszichofiziológia)
doi:	10.1016/j.brainresbull.2012.01.002
mtmt:	2802853
Online Access:	https://publikacio.ppke.hu/2383

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Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats.

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