rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia
  name:
    name part: Erdő Franciska
    role:
      role term: creator
  name:
    name part: Berzsenyi P
    role:
      role term: aut
  name:
    name part: Andrasi F
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 2005
    issuance: continuing
  language:
    language term: Ang
  language:
    language term: ol
  physical description:
    form: elektronikus dokumentum
    extent: 43-49
  abstract: Cerebroprotection after administration of glutamate receptor antagonists has been well documented. The present study is intended to determine whether the non-competitive alpha-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptor antagonist talampanel, known as antiepileptic drug, has neuroprotective effects in stroke models in rodents. The infarct size was measured in three models of stroke by 2,3,5-triphenyltetrazolium chloride staining. Therapeutic time window was also examined in rats subjected to 1h middle cerebral artery occlusion. The degree of neuroprotection was tested in mice, using 1.5, 2 h or permanent middle cerebral artery occlusions. Effect on photochemically induced thrombosis was investigated in rats applying 30 min time window after brain irradiation. Talampanel reduced the infarct size by 47.3% (p<0.01) after a 30 min delay and 48.5% (p<0.01) after 2 h delay following middle cerebral artery occlusion in rats. In mice, talampanel reduced the extension of the infarcted tissue at the levels of striatum and hippocampus by 44.5% (p<0.05) and 39.3% (p<0.01) after 1.5 h transient ischemia and still caused 37.0% (p<0.05) and 37.0% (p<0.05) inhibitions when 2 h occlusion was applied. In photothrombosis talampanel showed a 40.1% (p<0.05) inhibition. Protective actions of talampanel in various stroke models, in rats and mice, suggest a possible therapeutic role of the compound in stroke patients.
  note: Erdő Franciska
  subject:
    topic: Idegtudományok (benne pszichofiziológia)
  related item:
    title info:
      title: BRAIN RESEARCH BULLETIN 66 No. 1
  identifier: 0361-9230
  identifier: https://publikacio.ppke.hu/id/eprint/2378/1/brainresearchbulletin2005.pdf
  record info:
    record content source: PPKE Publikáció Repozitórium
    record creation date: 250307
    record change date: 20250307115549.0
    record identifier: publ2378
    language of cataloging:
      language term: hun