rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC3.4.14.5) produces naloxone-reversible analgesia in rats
  name:
    name part: Rónai András
    role:
      role term: creator
  name:
    name part: Timár Júlia
    role:
      role term: aut
  name:
    name part: Mako E
    role:
      role term: aut
  name:
    name part: Erdő Franciska
    role:
      role term: aut
  name:
    name part: Gyarmati Zsuzsanna
    role:
      role term: aut
  name:
    name part: Tóth Géza
    role:
      role term: aut
  name:
    name part: Orosz György
    role:
      role term: aut
  name:
    name part: Fürst Zsuzsanna
    role:
      role term: aut
  name:
    name part: Székely József Iván
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 1998
    issuance: continuing
  language:
    language term: Ang
  language:
    language term: ol
  physical description:
    form: elektronikus dokumentum
    extent: 145-152
  abstract: The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces st full, dose-dependent, short-lasting and naloxone- reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longitudinal muscle strip of guinea-pig ileum bioassay. Two of the potential DP IV substrates, morphiceptin and endomorphin 1, identified recently in bovine brain were also analgesic given by similar route. The action of endomorphin 1 was more potent (ED50 = 7.9 nmol/rat) and slightly but significantly more sustained than that of Diprotin A. Diprotin A neither potentiated nor prolonged the effect of a marginally analgesic dose of endomorphin 1. The distinct time course and the lack of potentiation indicate that in the analgesic effect of Diprotin A. in rats the protection of a brain Tyr-Pro-peptide other than endomorphin 1 is involved.
  note: Rónai András
  subject:
    topic: Farmakológia és gyógyszerészet
  related item:
    title info:
      title: LIFE SCIENCES 64 No. 2
  identifier: 0024-3205
  identifier: https://publikacio.ppke.hu/id/eprint/2338/1/lifescience1999.pdf
  record info:
    record content source: PPKE Publikáció Repozitórium
    record creation date: 250307
    record change date: 20250307110911.0
    record identifier: publ2338
    language of cataloging:
      language term: hun