rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats
  name:
    name part: Erdő Franciska
    role:
      role term: creator
  name:
    name part: Erdo SL
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 1998
    issuance: continuing
  language:
    language term: Ang
  language:
    language term: ol
  physical description:
    form: elektronikus dokumentum
    extent: 163-166
  abstract: Bimoclomol (BRLP-42) is a novel antiischemic compound acting against peripheral vascular complications of diabetes mellitus (neuropathy, retinopathy, and nephropathy). In the present study the activity of bimoclomol was tested in experimental subarachnoid hemorrhage (SAH) and arachidonic acid (AA)-induced brain edema in rats to elucidate whether the compound may also have beneficial effect in cerebrovascular disturbances. For comparison, a neuroprotective AMPA antagonist, GYKI-52466, was examined. Injury caused by autologous intracranial blood injection or sodium-arachidonate was evaluated by the damage of blood-brain barrier (BBB) reflected in the extravasation of Evans blue dye into the cerebral tissue. Bimoclomol (2 x 2 mg/kg IV) markedly reduced, while GYKI-52466 (2 x 2 mg/kg IV) moderately diminished the extravasation produced by SAH (39.9%, p < 0.01 and 26.7%, p > 0.05, respectively). In the case of AA-induced brain edema, bimoclomol showed less pronounced (19.6%, p < 0.05) inhibitory action, and GYKI-52466 seemed to be more effective (34.2%, p < 0.05). These results suggest that bimoclomol may be active not only in peripheral micro- and macroangiopathy, but also in some types of cerebrovascular disorders.
  note: Erdő Franciska
  subject:
    topic: Farmakológia és gyógyszerészet
  related item:
    title info:
      title: BRAIN RESEARCH BULLETIN 45 No. 2
  identifier: 0361-9230
  identifier: https://publikacio.ppke.hu/id/eprint/2337/1/bimoclomolprotects.pdf
  record info:
    record content source: PPKE Publikáció Repozitórium
    record creation date: 250305
    record change date: 20250305140109.0
    record identifier: publ2337
    language of cataloging:
      language term: hun