rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms
  name:
    name part: Chakravarty Suchana
    role:
      role term: creator
  name:
    name part: Hong Christian I.
    role:
      role term: aut
  name:
    name part: Csikász-Nagy Attila
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 2023
    issuance: continuing
  language:
    language term: Ang
  language:
    language term: ol
  physical description:
    form: elektronikus dokumentum
  abstract: Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops.
  note: Chakravarty Suchana
  subject:
    topic: Biokémia és molekuláris biológia
  subject:
    topic: Genetika és örökléstan
  subject:
    topic: Farmakológia és gyógyszerészet
  related item:
    title info:
      title: NPJ SYSTEMS BIOLOGY AND APPLICATIONS 9 No. 1
  identifier: 2056-7189
  identifier: https://publikacio.ppke.hu/id/eprint/1706/1/npj2023.pdf
  record info:
    record content source: PPKE Publikáció Repozitórium
    record creation date: 241119
    record change date: 20241119133728.0
    record identifier: publ1706
    language of cataloging:
      language term: hun