rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Systematic analysis of noise reduction properties of coupled and isolated feedforward loops
  name:
    name part: Chakravarty Suchana
    role:
      role term: creator
  name:
    name part: Csikász-Nagy Attila
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 2021
    issuance: continuing
  language:
    language term: Ang
  language:
    language term: ol
  physical description:
    form: elektronikus dokumentum
  abstract: Cells can maintain their homeostasis in a noisy environment since their signaling pathways can filter out noise somehow. Several network motifs have been proposed for biological noise filtering and, among these, feed-forward loops have received special attention. Specific feed-forward loops show noise reducing capabilities, but we notice that this feature comes together with a reduced signal transducing performance. In posttranslational signaling pathways feed-forward loops do not function in isolation, rather they are coupled with other motifs to serve a more complex function. Feed-forward loops are often coupled to other feed-forward loops, which could affect their noise-reducing capabilities. Here we systematically study all feed-forward loop motifs and all their pairwise coupled systems with activation-inactivation kinetics to identify which networks are capable of good noise reduction, while keeping their signal transducing performance. Our analysis shows that coupled feed-forward loops can provide better noise reduction and, at the same time, can increase the signal transduction of the system. The coupling of two coherent 1 or one coherent 1 and one incoherent 4 feed-forward loops can give the best performance in both of these measures. Copyright: © 2021 Chakravarty, Csikász-Nagy. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  note: Chakravarty Suchana
  subject:
    topic: Számelmélet
  subject:
    topic: Molekuláris biológia
  subject:
    topic: Genetika és örökléstan
  related item:
    title info:
      title: PLOS COMPUTATIONAL BIOLOGY 17 No. 12
  identifier: 1553-734X
  identifier: https://publikacio.ppke.hu/id/eprint/1702/1/ploscomputational2021.pdf
  record info:
    record content source: PPKE Publikáció Repozitórium
    record creation date: 241119
    record change date: 20241119093309.0
    record identifier: publ1702
    language of cataloging:
      language term: hun